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. 2021 May 5;12(3):1121–1143. doi: 10.1016/j.jcmgh.2021.04.016

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Supplementary data for regulation of TAK1 by MTDH. (A) RT-qPCR analysis and Western blotting analysis of MTDH expression in HCCLM3 cells on MTDH knockdown using 3 siRNAs. (B) RT-qPCR quantification of TAK1 and MTDH expression in SK-hep-1 and HepG2 cells transfected with MTDH siRNA or scramble control. (C) RT-qPCR quantification of E3 mRNAs expression in HCCLM3-SR cells transfected with MTDH siRNA or scramble control. (D) KEGG pathways significantly enriched in HCC patients with high expression of MTDH using TCGA data. (E) Western blotting analysis of MTDH and NF-κB pathway proteins in HCCLM3-SR and its parental cells; Western blotting analysis of MTDH and AKT pathway proteins in HCCLM3-SR and HepG2-SRs on MTDH knockdown. (F) Cell viability of HCCLM3 with stable expression MTDH treated with lenvatinib or regorafenib. (G) Relative cell viability and proportion of apoptotic cells in HCCLM3 cells transfected with MTDH siRNA or scramble control in combination with sorafenib or DMSO. Three biological repeats per group.