Fig. 1.

Relationship between INSM1 and Menin protein expression in PanNET human tissues with different genomic abnormalities. (A) Representative images of immunohistochemical staining of INSM1 and Menin of grade 3 surgically resected PanNET tumor tissues negative for PHLDA3 and MEN1 LOH, single PHLDA3 LOH and single MEN1 LOH. (B) INSM1 staining intensity in Human PanNET quantified by ImageJ. Values represents means of data obtained from five patient samples ± SD. **P-value < 0.01 as determined by t test.