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. 2021 Jul 26;14:682320. doi: 10.3389/fnmol.2021.682320

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Copyright © 2021 Dai, Wang, He, Xiong, Tian, Liu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lovastatin mitigates the acetylation of the histone induced by PFFs. (A) Western blot detecting the content of AcH4K5, AcH3K9, Histone 3, and Histone 4. (B) Quantification of AcH3K9. Results are normalized to Histone 3. (C) Quantification of AcH4K5. Results are normalized to Histone 4. All data are means ± SEM, *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.001, one-way ANOVA with Tukey’s multiple comparisons test. All experiments were performed in triplicate for at least three independent times.