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. 2021 Jul 26;11:735447. doi: 10.3389/fonc.2021.735447

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Copyright © 2021 He, Sun, Jiang, Chai, Li, Wang, Zhu, You, Li, Hao and Xin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-4277 represses the activation of cyp3a4’s 3’UTR luciferase reporters in MHCC97-H cells. The effect of miR-4277 on the activation of Luc-1 (the luciferase reporter with the wild type of the 1^st miR-4277 targeting site) or Luc-2 (the luciferase reporter with the wild type of the 2^nd miR-4277 targeting site), Luc-3 (the luciferase reporter with the wild type of the 1^st and 2^nd miR-4277 targeting site), Luc-4 (the luciferase reporter with the wild type of the 2^nd and the mutated 1^st miR-4277 targeting site), or Luc-5 (the luciferase reporter with the wild type of the 2^nd and the mutated 1^st miR-4277 targeting site) was examined. The results are shown as histograms. *P < 0.05.