Table 3.

miR-4277 enhanced the sensitivity of MHCC97-H cells to molecular targeted agents, regorafenib, lenvatinib, anlotinib, cabozantinib, or apatinib.

Groups	Regorafenib	Lenvatinib	Anlotinib	Cabozantinib	Apatinib
	IC50 values of the agents on MHCC97-H cells (μmol/L)
control miRNA	0.67 ± 0.49	0.55 ± 0.20	0.75 ± 0.03	0.51 ± 0.19	0.96 ± 0.33
miR-4277	0.22 ± 0.04	0.12 ± 0.06	0.10 ± 0.01	0.10 ± 0.04	0.26 ± 0.07
miR-4277 + CYP3A4Mut-1	0.33 ± 0.32	0.41 ± 0.01	0.30 ± 0.12	0.25 ± 0.06	0.52 ± 0.27
miR-4277 + CYP3A4Mut-2	0.35 ± 0.09	0.28 ± 0.11	0.45 ± 0.35	0.30 ± 0.21	0.46 ± 0.30
miR-4277 + CYP3A4Mut	0.71 ± 0.28	0.60 ± 0.20	0.78 ± 0.55	0.56 ± 0.15	0.98 ± 0.37