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Effect of miR-4277 on the clearance of sorafenib in the subcutaneous tumors formed by MHCC97-H cells.
| Groups | t1/2 of Sorafenib (hours) |
|---|---|
| control miRNA | 45.68 ± 5.31 |
| miR-4277 | 72.79 ± 7.52 |
| miR-4277 + CYP3A4Mut-1 | 52.38 ± 16.19 |
| miR-4277 + CYP3A4Mut-2 | 48.74 ± 28.50 |
| miR-4277 + CYP3A4Mut | 36.67 ± 12.58 |
