Table 5.

The effect of miR-4277 on sorafenib in HCC cells.

Sorafenib on HCC cells	Groups	HepG2	BEL-7402	SMMC-7721
t1/2 values (h)	control	30.30 ± 3.31	28.20 ± 8.67	25.70 ± 2.43
	miR-4277	56.43 ± 1.90	42.40 ± 3.33	46.25 ± 2.88
	miR-4277 + CYP3A4Mut	25.74 ± 4.47	26.36 ± 3.79	27.39 ± 6.93
IC50 values (μmol/L)	control	2.78 ± 0.59	1.79 ± 0.18	1.95 ± 0.54
	miR-4277	0.41 ± 0.07	0.28 ± 0.05	0.73 ± 0.33
	miR-4277 + CYP3A4Mut	3.56 ± 0.82	2.88 ± 0.35	1.92 ± 0.55