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The effect of potential inhibitors of CYP3A4 on sorafenib in MHCC97-H cells.
| Cell lines | Sorafenib on MHCC97-H | |
|---|---|---|
| t1/2 values (h) | IC50 values (μmol/L) | |
| Solvent control | 23.63 ± 0.70 | 0.68 ± 0.11 |
| ketoconazole | 44.17 ± 2.86 | 0.08 ± 0.01 |
| amprenavir | 33.85 ± 3.92 | 0.42 ± 0.05 |
| diltiazem | 37.40 ± 0.43 | 0.34 ± 0.10 |
