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. 2021 Aug 5;41(8):BSR20203531. doi: 10.1042/BSR20203531

Figure 4. The forest plot of the expression of OPN and clinical pathological features of PCAs.

Figure 4

(A) The relationship between OPN positive expression and Gleason score. The result showed that the positive rate of OPN in high Gleason score patients was significantly higher than the ones with low Gleason score (OR = 2.64, 95% CI [1.49, 4.70], P=0.0009). (B) The relationship between OPN positive expression and clinical stage. The result showed that the expression level of OPN in T III–IV stage is higher than that in T I–II stage of PCA patients (OR = 3.15, 95% CI [1.60, 6.20], P=0.0009). (C) The relationship between OPN positive expression and Whitmore-Jewett stage. The expression level of OPN in Whitmore-Jewett stage C+D patients is higher than in stage A+B patients. (OR = 2.53, 95% CI [1.06, 6.03], P=0.04). (D) The relationship between OPN positive expression and the differentiation of PCA. The expression of OPN have no difference between high and low differentiation of PCA tissues. (OR = 1.79, 95% CI [0.39, 8.33], P=0.46). (E) The relationship between OPN positive expression and the lymph node metastasis. The expression of OPN is positively correlated with lymph node metastasis of PCA. (OR = 3.69, 95% CI [1.88, 7.23], P=0.0001). (F) The relationship between OPN positive expression and distant metastasis of PCA. The expression of OPN is positively correlated with distant metastasis of PCA (OR = 8.10, 95% CI [2.94, 22.35], P=0.01).