Fig. 4.

Putative network to male reproductive AOs initiated in the MPW. The figure should be read from left to right and is organized in developmental time from top to bottom. Everything sharing the same vertical plane is thought to occur in that developmental window. The horizontal planes depict: 1) linear pathway network, 2) biological process and 3) gestational timing of events (E = embryonic day). KEs outlined in blue are those impacted during the MPW. The solid arrows indicate KER identified as part of the AOP and the dashed arrows indicate a mechanistic link where the event was not identified as a “key” part of the AOP. Hypothesized AOPs are underscored by a colored pathway- green for AOP1, blue for AOP2 and purple for AOP3. The dashed green between the MIE’s indicate they may be unique, as depicted, or shared. For the network it was determined that enough evidence existed to assume the unknown MIE for AOP’s 2 and 3 is shared as the two AOPs share the same early KE’s and it is unlikely that two distinct MIE’s would converge on the same early KE. AOP1 could not be linked to the other AOPs with any known early KE’s therefore, until otherwise demonstrated, the MIE is depicted as a unique event. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)