Table 2.

Dose, temporal and incidence concordance of KEs in AOP1. Observations as reported by Gray et al. (2016) on dipentyl phthalate (DPP) support concordance of KEs. A dash (−) indicates no effect; a plus (+) indicates effect observed; number of pluses indicates increased severity/incidence. Severity/incidence of effect weighting are provided as part of Supplemental Table 2. An AOP supported by empirical data shows early events occurring at lower doses and with higher severity than later events. GD = gestational day; mo. = months.