Table 4.

Dose-response and temporal concordance of KE in AOP2. Observations as reported in van den Driesche et al. (2012) on DBP support concordance of early KEs with the AO. A dash (-) indicates no effect; a plus (+) indicates effect observed; number of pluses indicates increased severity/incidence; a blank cell indicates event not measured. Severity/incidence of effect weighting are provided as part of Supplemental Table 5. An AOP supported by empirical data shows early events occurring at lower doses and with higher severity than later events.