Table 6.

Dose, temporal and incidence concordance of KEs in AOP. Observations as reported in Gray et al. (2016) on DPP, supports concordance of a subset of KEs. A dash (−) indicates no effect; a plus (+) indicates effect observed; number of pluses indicates increased severity/incidence; a blank cell indicates event not measured. Note for KE2, the severity of effect at a given dose varied among the steroidogenesis genes. The severity indices here reflects an average impact between StAR, CYP17 and CYP11. Severity/incidence of effect weighting are provided as part of Supplemental Table 9. While sperm parameters were reported, parameters of impact on sperm maturation were not reported. An AOP supported by empirical concordance shows early events occurring at lower doses and with higher severity than later events. GD = gestational day; mo. = months.