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. 2021 Jul 26;12:701282. doi: 10.3389/fimmu.2021.701282

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Copyright © 2021 Bai and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The assembly and activation of The NLRP3 inflammasome. The NLRP3 inflammasome is a complex composed of NLRP3, ASC and caspase-1 precursor proteins, in which NLRP3 protein plays a leading role. ASC is a cohesive protein of this specific inflammasome, whose amino terminal contains pyrin domain and carboxyl terminal contains CARD domain. The initiation signals of activating NLRP3 inflammasome are some internal and external activators, including a variety of PAMP and DAMP. NLRP3, nucleotide-binding domain leucine-rich repeat and pyrin domain containing receptor protein 3; ASC, apoptosis associated speck like protein containing cysteine aspartic proteinase recruitment domain; CARD, cysteine aspartic proteinase recruitment domain; PAMP, pathogen-associated molecular patterns; DAMP, danger associated molecule patterns.