Table 1.

The activated mode and steps of NLRP3 inflammasome and the theories that explain these activation.

	Activating molecules	Activation steps	Theories for explaining these activation
PAMP	Calcium pyrophosphate, sodium, LPS, urate, palmitate, cholesterol, etc.	Inducing inflammation, oligomerization of NLRP3, assembly of ASC and caspase-1 precursor protein.	Active oxygen theory, lysosomal damage theory, mitochondrial DNA theory
DAMP	Hypokalemia, hypercalcemia, cathepsin B, Silica, Aβ, ATP, hyperglycemia, ROS, etc.	oligomerization of NLRP3, assembly of ASC and caspase-1 precursor protein.	Active oxygen theory, mitochondrial DNA theory