Table 2.
The concentration of enrofloxacin (ENR), ciprofloxacin (CIP) and lincomycin (LIN) in whole egg, egg white, egg yolk, and eggshell after multiple oral administration of ENR and LIN to laying hens.
| Concentration ± SD* µg/kg |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ENR |
CIP |
LIN |
||||||||||||
| Period | Time (d) | Eggshell | Whole egg | Egg yolk | Egg white | Eggshell | Whole egg | Egg yolk | Egg white | Eggshell | Whole egg | Egg yolk | Egg white | |
| Administration | 0 | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | |
| 1 | 573 ± 52 | 518 ± 86 | 517 ± 170 | 1423 ± 160 | 38.6 ± 15 | 27.1 ± 1.3 | 4.7 ± 2.0 | 21.0 ± 2.4 | 4.6 ± 0.9 | 20.1 ± 2.5 | 4.7 ± 0.5 | 22.4 ± 5.6 | ||
| 2 | 705 ± 63 | 1087 ± 119 | 1075 ± 150 | 1970 ± 150 | 83.4 ± 9.5 | 26.2 ± 1.6 | 9.7 ± 6.2 | 51.5 ± 5.7 | 14.0 ± 2.5 | 35.7 ± 4.8 | 7.4 ± 1.3 | 47.2 ± 8.5 | ||
| 3 | 655 ± 34 | 1593 ± 129 | 1023 ± 120 | 1566 ± 140 | 97.6 ± 15 | 33.4 ± 0.6 | 8.3 ± 4.6 | 41.7 ± 10 | 14.9 ± 1.3 | 34.5 ± 6.6 | 22.8 ± 5.5 | 44.4 ± 6.3 | ||
| 4 | 788 ± 45 695 ± 63 |
1856 ± 109 | 1253 ± 97 | 1721 ± 90 | 203 ± 14 | 32.9 ± 1.0 | 14.3 ± 7.2 | 64.0 ± 4.7 | 12.9 ± 2.0 | 43.2 ± 9.7 | 24.2 ± 4.4 | 34.1 ± 3.8 | ||
| Depletion | 5 | 1910 ± 203 | 1207 ± 180 | 1230 ± 85 | 24.5 ± 4.1 | 43.1 ± 10 | 60.1 ± 4.2 | 37.1 ± 5.1 | 12.4 ± 1.3 | 40.8 ± 1.9 | 25.8 ± 4.3 | 17.2 ± 3.7 | ||
| 6 | 209 ± 54 | 1540 ± 86 | 1278 ± 100 | 946 ± 96 | 7.9 ± 2.8 | 48.0 ± 5.7 | 86.4 ± 8.2 | 36.4 ± 1.5 | 1.8 ± 1.2 | 18.7 ± 5.1 | 39.2 ± 1.8 | 4.6 ± 2.3 | ||
| 7 | 15.5 ± 3.7 | 523 ± 107 | 1073 ± 150 | 310 ± 15 | <LOQ | 53.8 ± 7.7 | 109 ± 7.0 | 5.5 ± 0.2 | <LOQ | 16.5 ± 3.9 | 31.4 ± 2.8 | 1.8 ± 0.7 | ||
| 8 | 7.5 ± 3.2 | 246 ± 49 | 615 ± 94 | 62.6 ± 11 | <LOQ | 32.3 ± 5.5 | 110 ± 11 | <LOQ | <LOQ | 7.0 ± 1.9 | 27.1 ± 5.3 | <LOQ | ||
| 9 | 5.2 ± 2.1 | 128 ± 19 | 381 ± 17 | 40.2 ± 5.8 | <LOQ | 30.6 ± 2.5 | 69.9 ± 13 | <LOQ | <LOQ | 4.5 ± 1.1 | 5.7 ± 1.7 | <LOQ | ||
| 10 | 2.8 ± 0.7 | 24.8 ± 5.6 | 329 ± 12 | 13.8 ± 4.1 | <LOQ | 4.9 ± 3.5 | 63.6 ± 12 | <LOQ | <LOQ | <LOQ | 1.3 ± 0.6 | <LOQ | ||
| 11 | 2.8 ± 0.7 | 19.1 ± 5.2 | 195 ± 7.4 | 12.2 ± 0.6 | <LOQ | 6.0 ± 2.5 | 20.9 ± 3.6 | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | ||
| 12 | 2.9 ± 0.4 | 11.3 ± 6.3 | 126 ± 8.3 | 4.3 ± 1.2 | <LOQ | 5.1 ± 2.8 | 24.0 ± 11 | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | ||
| 13 | 1.9 ± 0.5 | 4.5 ± 2.3 | 22.0 ± 3.5 | 3.2 ± 0.6 | <LOQ | 2.7 ± 1.9 | 17.7 ± 2.3 | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | ||
| 14 | 1.7 ± 0.5 | 3.0 ± 0.6 | 2.3 ± 0.5 | 3.5 ± 0.4 | <LOQ | 1.4 ± 0.7 | 4.7 ± 1.4 | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | ||
| 15 | <LOQ | 2.5 ± 0.1 | 2.5 ± 0.5 | 2.4 ± 1.0 | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | ||
| 16 | <LOQ | 1.5 ± 0.1 | 1.8 ± 0.2 | 2.0 ± 0.3 | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | ||
| 17 | <LOQ | 1.4 ± 0.1 | 1.4 ± 0.1 | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | ||
| 18 | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | <LOQ | ||
Abbreviation: LOD, limit of quantification.
⁎
Mean concentration ± SD, with n = 6–8 (whole egg, eggshell), n = 3–4 (egg white, egg yolk).