Fig. 2.

Lipid profile of 3 hepatic phenotypes.

(A) Boxplots showing FFA, LPC, and TG levels from hepatic vein for the 3 hepatic phenotypes. These 3 lipid classes were selected here because their levels changed after alcohol intervention in at least 1 phenotype (Table 2). FFA showed significant changes over time in Control, ALD, and NAFLD phenotypes, while LPC showed significant changes over time in the Control phenotype. TG showed significant changes over time in ALD and NAFLD phenotypes. Significances were based on p <0.0039. (B) Forrest plot showing magnitude of change after alcohol intervention (estimate coefficients derived from mixed models) for all 13 lipid classes from hepatic vein in each hepatic phenotype. (C) Boxplots comparing FFA, LPC, and TG levels in hepatic and systemic veins. The lines connect the means of boxes. ALD, alcohol-related liver disease; CTL, healthy control; FFA, free fatty acid; LPC, lysophosphatidylcholine; NAFLD, non-alcoholic fatty liver disease; TG, triglyceride.