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. 2021 Jun 29;3(5):100325. doi: 10.1016/j.jhepr.2021.100325

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© 2021 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 3 — Changes in lipid levels after alcohol intervention.

(A) Volcano plot showing changes in levels (mixed model estimate coefficients) for 252 lipids from hepatic vein after alcohol intervention. Statistical significance (y-axis) is plotted against the magnitude of change in the lipid levels after alcohol intervention (x-axis) to identify the most dynamic lipids that were also statistically significant. Different colours represent different lipid species, and larger dots represent the 24 lipids passing Bonferroni threshold (p <1.98×10^-04). (B) Forrest plot showing magnitude of change after alcohol intervention (mixed model estimate coefficients) for the 24 lipids from hepatic vein selected from Fig. 3A. Cer, ceramide; DG, diglyceride; FFA, free fatty acid; HexCer, hexosylceramide; LacCer, lactosylceramides; LPC, lysophosphatidylcholine; LPE, lysophosphatidylethanolamine; NAFLD, non-alcoholic fatty liver disease; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PI, phosphatidylinositol; SHexCer, sulfatides hexosylceramide; SM, sphingomyelin; TG, triglyceride.