Table 3.
Summary of mixed models showing relative changes in FFA, LPC, and TG levels from baseline to 180 min after start of alcohol intake.
| Lipid class | Hepatic vein: estimate coefficients (95% CI) |
Systemic vein: estimate coefficients (95% CI) |
||||||
|---|---|---|---|---|---|---|---|---|
| All | Controls | ALD | NAFLD | All | Controls | ALD | NAFLD | |
| FFA | -39.42∗ (-50.95~-27.89) p < 0.0001 |
-31.02∗ (-50.13~-11.90) p = 0.0030 |
-44.36∗ (-65.28~-23.44) p = 0.0002 |
-40.41∗ (-61.08~-19.74) p = 0.0004 |
-37.91∗ (-50.00~-25.82) p <0.0001 |
-45.97 (-76.04~-15.89) p = 0.0047 |
-30.67∗ (-48.95~-12.40) p = 0.0002 |
-39.29∗ (-58.91~-19.67) p = 0.0003 |
| LPC | -14.08∗ (-21.28~-6.87) p = 0.0002 |
-23.96∗ (-33.88~-14.04) p < 0.0001 |
-20.97 (-34.68~-7.26) p = 0.0041 |
-1.05 (-12.64~10.53) p = 0.854 |
-14.84∗ (-21.11~-8.56) p <0.0001 |
-15.50(-30.02~-0.98) p = 0.0377 |
-20.52 (-31.86~-9.18) p = 0.0041 |
-9.09 (-17.96~-0.23) p = 0.0448 |
| TG | 12.00 (2.16~21.84) p = 0.0176 |
25.20∗ (11.19~39.22) p = 0.0013 |
17.52∗ (6.33~28.70) p = 0.0034 |
-1.95 (-23.56~19.65) p = 0.855 |
16.53∗ (8.92~24.14) p <0.0001 |
12.88 (-7.02~32.77) p = 0.1913 |
19.49∗ (6.49~32.50) p = 0.0034 |
16.20∗ (5.77~26.63) p = 0.0035 |
The table shows estimate coefficients (change in relative levels of lipid every minute after alcohol intervention) and their p values are shown.
ALD, alcohol-related liver disease; FFA, free fatty acid; LPC, lysophosphatidylcholine; NAFLD, non-alcoholic steatohepatitis; TG, triglyceride.
∗
Passed Bonferroni procedure p <0.0039.