Table. 2.
Expression of ABCB1 on the skin
| Skin compartment | Relative expression* | Functions |
|---|---|---|
| Epidermis | ||
| Keratinocytes | Intermediate | ABCB1 mostly detected in the suprabasal keratinocytes [28] |
| Dermis | ||
| Vasculature | High | Presumed functions for drug transport to the bloodstream and barriers of xenobiotics [26] |
| Adipocyte | Intermediate | Functions unknown [26] |
| Nerve sheath | High | Functions unknown [26] |
| Musculature | High | Functions unknown [26] |
| Appendages | ||
| Sebaceous glands | Undetermined in human | ABCB1 expressed in the murine sebocytes; may be involved in the pathogenesis of acne [29] |
| Hair follicles | High | Highest expression on the inner root sheath, outer root sheath, connective tissue sheath, and arrector pili muscle; also expressed on the epithelium and dermal papillae. May be involved in stem cell features [27, 30] |
| Sweat glands | High | Presumed functions for drug transport to the sweat ducts [26] |