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. 2021 Jul 26;9:705774. doi: 10.3389/fbioe.2021.705774

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Copyright © 2021 Sun, Zhang, Luo, Hu, Zheng, Huang, Greven, Hildebrand and Yuan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Construction of bone defect and implantation of designed scaffolds. (B) 3D reconstruction of bone tissues through micro-computed tomography (CT) analysis at 4 and 12 weeks (red: new bones; grey: scaffolds). Quantitative analysis of (C) bone volume/total volume (BV/TV) and (D) bone mineral density (BMD).