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Patients with cholestatic cirrhosis had elevated serum bile acid and TGR5 expression levels. (A) Analysis of BAs in cholestatic cirrhosis patients (n=30) and controls (n=30); (B) real-time PCR analysis of TGR5 mRNA level (n=30); (C,D) Western blot analysis of TGR5 protein level (n=12). The densitometric analysis is shown as (D). ***P<0.001. BAs, bile acids; PCR, polymerase chain reaction.
