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. 2021 Jul;9(14):1158. doi: 10.21037/atm-21-2631

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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TGR5−/− BDL mice showed increased oxidative stress and pro-inflammatory response. WT or TGR5−/− mice underwent BDL. (A) MDA and CAT activities in liver tissues on Day 10 (n=3 per group); (B) TNF-α and IL-6 level on Day 1, 3, 7, and 10 measured by ELISA (n=3 per group); (C) TGR5, TLR4, and HO-1 expression in liver on Day 10 (n=3 per group); (D) the expression levels of NF-κB (nuclear and cytoplasmic) and Nrf2 (nuclear and cytoplasmic) in liver on day 10 (n=3 per group). **P<0.01, ***P<0.001 (vs. control); ^#P<0.05, ^##P<0.01 (vs. WT). BDL, bile duct ligation. MDA, malondialdehyde; CAT, catalase.