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. 2021 Jul;9(14):1120. doi: 10.21037/atm-21-684

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Pain-relieving effects of DLTH in DMM-induced osteoarthritis. (A) Effects of DLTH treatment on the NRT values in OA mice. (B) Serum level profiles of PGE2 in all groups. (C) Pain-relieving effects of DLTH on gene expressions of pro-inflammatory and pain-related factors in DRGs. All data are presented as a value relative to those in the Ctrl group. All data were expressed as mean ± SEM. ^###P<0.001, ^####P<0.0001; *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001. Ctrl, control; DLTH, dexamethasone-loaded thermo-sensitive hydrogel; DMM, destabilization of the medial meniscus; DRGs, dorsal root ganglia; NRT, nociceptive response time; OA, osteoarthritis; PGE2, prostaglandin E2; SEM, standard error of the mean.