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. 2021 Jul;9(14):1150. doi: 10.21037/atm-21-2625

Figure 4.

Figure 4

ETV1 p.E462Q and p.P159S mutations promoted ASCL1 expression in SCLC. (A) Real time-PCR was used for the mRNA expression of ETV1 after transfection of the ETV1 WT and mutant plasmids. (B,C) ASCL1 and HES1 mRNA levels in cells transfected with ETV1 mutant plasmids compared with those in cells transfected with the ETV1 WT plasmid. (D) Cell proliferation of H69 cells after transfection of the ETV1 WT and mutant plasmids. *, P<0.05; **, P<0.01; ***, P<0.001. ASCL1, achaete-scute homolog 1; SCLC, small cell lung cancer; ETV1, ETS variant transcription factor 1; WT, wild-type.