Table 3. Univariate and multivariate associations between EPVS and HT.

Imaging variables	Unadjusted			Model 1			Model 2			Model 3
	OR (95% CI)	P		OR (95% CI)	P		OR (95% CI)	P		OR (95% CI)	P
Total EPVS	0.723 (0.589–0.887)	0.002		0.749 (0.581–0.965)	0.025		0.770 (0.593–1.000)	0.050		0.817 (0.617–1.081)	0.157
BG-EPVS	0.638 (0.454–0.897)	0.010		0.681 (0.448–1.037)	0.073		0.703 (0.459–1.078)	0.106		0.785 (0.499–1.235)	0.294
BG-EPVS (0–1 vs. 2–4)	0.474 (0.287–0.782)	0.003		0.571 (0.304–1.076)	0.083		0.595 (0.313–1.130)	0.113		0.674 (0.336–1.350)	0.265
CS-EPVS	0.690 (0.502–0.949)	0.022		0.720 (0.492–1.053)	0.090		0.752 (0.509–1.112)	0.153		0.784 (0.517–1.191)	0.254
CS-EPVS (0–1 vs. 2–4)	0.585 (0.304–1.125)	0.108		0.530 (0.242–1.160)	0.112		0.583 (0.262–1.300)	0.188		0.792 (0.334–1.879)	0.597
Total CSVD burden	0.669 (0.500–0.895)	0.007		0.721 (0.495–1.051)	0.089		0.725 (0.495–1.062)	0.099		0.813 (0.533–1.240)	0.337
Score 0	Reference			Reference			Reference			Reference
Score 1	0.550 (0.314–0.863)	0.036		0.533 (0.267–1.064)	0.074		0.532 (0.264–1.072)	0.077		0.580 (0.275–1.224)	0.153
Score 2	0.380 (0.171–0.842)	0.017		0.423 (0.160–1.117)	0.082		0.398 (0.148–1.072)	0.068		0.451 (0.151–1.344)	0.153
Score 3	0.460 (0.155–1.366)	0.162		0.631 (0.164–2.435)	0.504		0.708 (0.184–2.729)	0.708		1.260 (0.287–5.524)	0.759

Model 1: adjusted for age, sex, stroke onset to admission time, AF, smoking, alcohol consumption, baseline NIHSS, systolic pressure, TOAST classification, platelet, NLR; Model 2: model 1+ treatment after admission; Model 3: model 2+ Infarct area >1/3MCA. HT, hemorrhagic transformation; BG-EPVS, basal ganglia enlarged perivascular spaces; CS-EPVS, centrum semiovale enlarged perivascular spaces; CSVD, cerebral small vessel disease; OR, odds ratio; CI, confidence interval.