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. 2021 Jul 26;11:659200. doi: 10.3389/fonc.2021.659200

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Copyright © 2021 Zhu, Xie, Yu, Yao, Xu, Huang, Wu, Li, Zheng, Liu, Xie, Huang, Li, Zheng, Zhang, Qiao, Chan and Zhou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Enrichment plot showing biological signatures based on gene set enrichment analysis (GSEA) of KEAP1/NFE2L2 mutant NSCLC. (A): Significant down-regulation in multiple DDR-related pathways including base excision repair, DNA repair, fanconi anemia pathway, G2 M DNA damage checkpoint, HDR through HRR and nucleotide excision repair. (B): Significant down-regulation in CD4 T cell (the green and blue curves) and NK T cell (the purple curve), significant up-regulation in T regulation cell (the pink curve).