Table 4.

Association of SNPs in VEGFA, VEGFR1, VEGFR2, and KRAS genes with OS and PFS.

Gene	RF number	Alleles	OS		PFS
			HR (CI 95%)	p	HR (CI 95%)	p
VEGFR-1	rs9582036	CC	REF	–	–	–
		AA	0.39 (0.20 - 0.78)	0.007	0.47 (0.26 - 0.85)	0.012
		AC	0.54 (0.29 – 1.03)	0.060	0.54 (0.30 – 0.96)	0.035
	rs7996030	GG	REF	–	–	–
		AA	1.29 (0.40 - 4.18)	0.674	1.82 (0.72 - 4.58)	0.206
		AG	1.25 (0.80 - 1.94)	0.328	1.31 (0.92 – 1.87)	0.134
VEGFR-2	rs2071559	AA	REF	–	–	–
		GG	1.42 (0.77 - 2.63)	0.260	1.40 (0.86 - 2.27)	0.175
		AG	1.23 (0.74 – 2.05)	0.423	1.16 (0.77 - 1.74)	0.473
	rs870377	AA	REF	–	–	–
		TT	0.70 (0.30 - 1.65)	0.418	0.77 (0.35 - 1.68)	0.512
		AT	0.85 (0.35 - 2.03)	0.713	0.83 (0.38 - 1.84)	0.648
VEGF-A	rs3025039	CC	REF	–	–	–
		TT	0.45 (0.21 - 0.99)	0.048	(0.59 - 1.61)	0.917
		CT	0.54 (0.28 – 1.05)	0.068	(0.43 – 1.16)	0.172
	rs833061	CC	REF	–	–	–
		TT	0.88 (0.50 - 1.56)	0.666	0.86 (0.53 - 1.40)	0.82
		CT	0.65 (0.38 - 1.08)	0.097	0.82 (0.54 – 1.24)	0.354
	rs2010963	CC	REF	–	–	-
		GG	1.59 (0.57 - 4.45)	0.378	0.89 (0.42 - 1.87)	0.762
		CG	1.52 (0.55 – 4.26)	0.421	0.77 (0.36 – 1.62)	0.484
KRAS	rs10842513	CC	REF	–	–	–
		TT	0.81 (0.11 - 5.87)	0.836	1.15 (0.28 - 4.69)	0.841
		CT	1.26 (0.69 – 2.28)	0.455	1.39 (0.85 - 2.27)	0.192
	rs12813551	CC	REF	–	–	–
		TT	0.44 (0.17 - 1.14)	0.092	0.86 (0.46 - 1.60)	0.635
		CT	0.91 (0.58 – 1.41)	0.662	0.95 (0.66 - 1.37)	0.773
	rs10505980	CC	REF	–	–	–
		TT	0.65 (0.29 - 1.47)	0.288	1.32 (0.76 - 2.31)	0.328
		CT	0.86 (0.55 – 1.35)	0.517	0.93 (0.64 - 1.34)	0.693

Multiple Cox-regression allelic model for PFS and OS was performed.

P-values marked with bold indicate statistically significant p-values.