Table 2.

Associations of 1/Urinary Creatinine With Composite CVD Events, Mortality, and the Composite Kidney Outcome

	HR (95% CI)	HR (95% CI)	HR (95% CI)
	Model 1	Model 2	Model 3
Primary CVD events (307 events)	1.23 (1.08-1.39)	1.15 (1.01-1.32)	1.27 (1.11-1.45)
All-cause mortality (166 events)	1.07 (0.89-1.27)	0.96 (0.80-1.15)	1.06 (0.87-1.28)
Composite kidney outcome (34 events)	1.75 (1.25-2.44)	1.11 (0.75-1.65)	1.49 (0.95-2.35)

Note: All biomarker HRs are per 2-fold increase. Model 1: age, sex, race, and randomization arm. Model 2: model 1 plus baseline estimated glomerular filtration rate, smoking status, history of CVD, baseline number of antihypertensive medications, systolic blood pressure, diastolic blood pressure, body mass index, and high-density lipoprotein and total cholesterol levels. Model 3: adjusted for all factors plus urinary albumin level.

Abbreviation: CVD, cardiovascular disease; HR, hazard ratio.