Table 2.
Summary of Relevant Previous Literature: Kidney Amyloidosis With Presentation Concerning for Crescentic Glomerulonephritis
| Study | Study Type | Patient Presentation/Study Population | Diagnosis | Kidney Biopsy Findings/Study Findings | Outcome |
|---|---|---|---|---|---|
| Murakami et al7 (1998) | Case report | 43 F with 8-y history of RA presenting with hypertension, proteinuria, hematuria, pyuria, and AKI | AA amyloidosis | 70%-80% fibrocellular crescents and moderate amyloid deposits | Death |
| Bernheim and Bernheim6 (1999) | Case report | 80 F with history of RA presenting with nephrotic syndrome and rapidly progressive kidney failure | AA amyloidosis | Amyloid deposition staining positive with anti-amyloid A antibody with fibrocellular and fibrous crescents, interstitial fibrosis, focal lymphocytic infiltration, and tubular atrophy | Not reported |
| Nagata et al4 (2001) | Retrospective analysis | 105 kidney specimens (44 biopsies, 61 autopsies) with amyloidosis | N/A | Of 105 specimens with any amyloidosis, 14 (13.3%) demonstrated crescents; of these 14, the associated disease in 11 specimens was RA; there was 1 case of each of the following: macroglobulinemia, plasma cell dyscrasia, multiple myeloma | N/A |
| Schafernak et al5 (2005) | Case report | 62 F with RA, insulin-dependent type 2 diabetes mellitus, hypertension, coronary artery disease, and hypothyroidism presenting with AKI and proteinuria | AA amyloidosis | Amyloid deposition in mesangium, 60% fibrocellular crescents, diffuse proliferative hypercellular lesions rich in polymorphs and monocytes, 11% glomerular sclerosis, moderate tubular atrophy, and scattered interstitial cellular infiltrates with lymphocytes, monocytes, and plasma cells | Hemodialysis-dependent after 17 mo |
| Crosthwaite et al10 (2010) | Case report | 67 M with history of AL amyloidosis with known kidney and cardiac involvement and recently diagnosed with IgG κ multiple myeloma presenting with AKI and hematuria | AL amyloidosis and multiple myeloma | Amyloidosis with segmental necrotizing lesions and cellular crescents | Remained on hemodialysis until death after 6 mo |
| Said et al3 (2013) | Retrospective analysis | 474 kidney biopsy specimens with amyloidosis in single academic center 2007-2011 | N/A | Of 474 specimens, 5 (1.1%) demonstrated crescents; of the 384 specimens with AL amyloidosis, 3 (0.8%) demonstrated crescents | N/A |
| Liangos et al11 (2015) | Case report | 73 M with history of MGUS presenting with fever and multiorgan dysfunction featuring kidney failure with nephrotic-range proteinuria and microhematuria with erythrocyte casts. | AL amyloidosis | AL amyloidosis and tubular atrophy; no crescents or evidence of GN or vasculitis | Kidney function recovery |
Abbreviations: AKI, acute kidney injury; GN, glomerulonephritis; IgG, immunoglobulin G; MGUS, monoclonal gammopathy of unknown significance; N/A, not applicable; RA, rheumatoid arthritis.