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. 2021 Jul 20;13(8):e13901. doi: 10.15252/emmm.202013901

Figure 3. Schematic depiction of glycolysis and related metabolic networks in latently HIV‐1‐infected Jurkat T cells.

Figure 3

The regulation of metabolic pathways was reconstructed based on the metabolomic data of latently infected Jurkat T cells (2D10) as compared to their uninfected counterpart (E6). Enzymes are shown in italics. The figure includes the main energetic pathways described in the paper, as well as relevant connections with pathways that were significantly enriched in the analysis shown in Fig 2A (gray boxes). The red arrows indicate the proposed path of the glucose carbon chains in latently infected cells. Solid lines indicate direct connections. Dashed lines indicate indirect connections involving intermediate metabolites not shown in the figure. Networks were built using the Cytoscape software (http://www.cytoscape.org) and the MetScape plugin (http://metscape.ncibi.org/tryplugin.html) (Gao et al, 2010) and adapted using Adobe Illustrator (v 16.03). ACLY = ATP citrate lyase; ACO = aconitase; ADPGK = ADP‐dependent glucokinase; ALDO = fructose 1,6 bisphosphate aldolase; ENO1 = enolase 1; FBP1 = fructose‐bisphosphatase; PFK = phosphofructokinase 1; FH = fumarate hydratase; H6PD = hexose‐6‐phosphate dehydrogenase; HK1 = hexokinase 1; G6PD = glucose‐6‐phosphate dehydrogenase; GAPDH = glyceraldehyde 3‐phosphate dehydrogenase; GCK = glucokinase; GPDH = glycerol 3‐phosphate dehydrogenase; GPI = glucose‐6‐phosphate isomerase; KORA = ketoglutarate dehydrogenase A; IDH = isocitrate dehydrogenase; LDHAL6A = lactate dehydrogenase A like 6A; MDH1 = malate dehydrogenase 1; PCK1 phosphoenolpyruvate carboxykinase 1; PFK = phosphofructokinase; PGAM4 = phosphoglycerate mutase family member 4; PGD = 6‐phosphogluconate dehydrogenase; PGK1 = phosphoglycerate kinase 1; PGLS = 6‐phosphogluconolactonase; PGM1 = phosphoglucomutase 1; PKLR = pyruvate kinase L/R; PRPS1 = ribose phosphate pyrophosphokinase 1; RPIA = ribose 5‐phosphate isomerase; SDHA = succinate dehydrogenase complex flavoprotein subunit A; SUCD = succinate semialdehyde dehydrogenase; TKT = transketolase; TPI = triose phosphate isomerase.