Figure 2.

Cellular responses to SARS-CoV-2 vaccination in IS patients. (A) T-cell responses to spike protein peptides of SARS-CoV-2 in infection-naïve patients at baseline, 28–40 days following first-dose vaccine and 18–29 days after second-dose vaccine. (B) T-cell responses in those receiving tacrolimus therapy versus those who were not in infection-naïve participants at baseline, after first-dose vaccine and after second-dose vaccine. (C) T-cell responses by vaccine type in infection-naïve participants at baseline, after first-dose vaccine and after second-dose vaccine. (D) T-cell responses following first-dose and second-dose vaccinations in healthy volunteers (HVs), IS patients and a matched cohort of IS patients. (E) T-cell responses following second-dose vaccine in those who did and did not also seroconvert. (F) Correlation of T-cell responses after second-dose vaccination and age at time of vaccination. Dotted line indicates mean plus 3 SDs for spike peptide pool reactivity calculated from infection-naïve, non-vaccinated individuals (40 SFU/10⁶ PBMC). For visualisation of data on a log scale, values=0 are represented by 0.1. HV, healthy volunteer; IS, immunosuppressed; PMBC, peripheral blood mononuclear cell; SFU, spot-forming unit.