Table 1. Recurrent HBV target genes.

Sample No	Sequencing	Cancer related genes	Cancer non-related genes	Reference
40	MAPS	TERT [6], CCNA2 [1], KMT2B [1]	SMAD5 [2]	(7)
81	WGS	TERT [18], KMT2B [9], CCNE1 [4]	SEMP5 [3], ROCK1 [2]	(1)
28	Capture	TERT [7], KMT2B [5], CCNE1 [2]		(8)
79	WES	TERT [17], KMT2B [6], CCNE1 [1], CCNA2 [1]	ALOX5 [2], ZFPM [2], SENP [2], MYO19 [2], RGS [2]	(10)
22	WGS	TERT [2], KMT2B [5]		(9)
426	Capture	TERT [101], KMT2B [15], CCNE1 [7], CCNA2 [8]	ANKRD30BL [7], FAM157A [7], DDX11L1 [23] DDX11L5 [8], DDX11L9 [8]	(11)
42	Capture	TERT [8], KMT2B [6], CCNA2 [1]		(5)
154*	Capture	TERT [19], KMT2B [7], CCNE1 [1], CCNA2 [1]	DDX11L1 [2], DDX11L2 [2], DDX11L16 [2] CWH43 [2], DEBT [2], EYA1 [2], MACROD2 [2] PTPRD [2], ZNF595 [2]	(6)
177	Capture	TERT [48], KMT2B [3], CCNE1 [4], CCNA2 [1]	AHRR [2], NRG1 [2], TRIM161 [2], ST18 [2]	(4)

*, including both patients with chronic and prior HBV infection. Data sets in which ≥20 cases were analyzed are chronologically listed. The numbers in square brackets correspond to the patient numbers. HBV, hepatitis B virus; MAPS, massive anchored parallel sequencing; WGS, whole-genome sequencing; WES, whole-exome sequencing.