Table 1. Role of NASH-specific CD8+ T cell.
NASH mouse model |
● CD8+PD-1+ T cell is increased over time |
● Hepatocyte damage/fibrosis is induced by TNF produced by CXCR6+FOXO1low PD-1high CD8+ T cell |
● This resident like T cell is induced by IL-15 |
● Hepatocyte death is mainly induced by Fas ligand dependent apoptosis |
NASH HCC mouse model |
● CD8+PD-1+ T cell is increased |
● No tumor response to anti-PD-1 Ab |
● HCC is induced by activated CD8+ T cell (CXCR6+FOXO1low PD-1high CD8+ T cell) |
● PD-1 antibody promotes HCC incidence through increased CD8+PD-1+ T cell |
NASH, non-alcoholic steatohepatitis; PD-1, programmed cell death 1; HCC, hepatocellular carcinoma.