Table 4. Safety summary.

AEs	Any grade, n (%)	Grade 3, n (%)
Fatigue	6 (66.7)	1 (11.1)
Hypertension	5 (55.6)	2 (22.2)
ALT or AST elevation	6 (66.7)	0 (0.0)
Hypothyroidism	1 (11.1)	0 (0.0)
Decreased appetite	5 (55.6)	1 (11.1)
Abdominal pain	1 (11.1)	0 (0.0)
Vomiting	2 (22.2)	0 (0.0)
Skin rash	3 (33.3)	1 (11.1)
Anaemia	1 (11.1)	0 (0.0)
Diarrhoea	1 (11.1)	0 (0.0)
Hand-foot syndrome	2 (22.2)	0 (0.0)
Leukocytopenia	2 (22.2)	1 (11.1)
Nasal haemorrhage	4 (44.4)	1 (11.1)
Asthma	1 (11.1)	1 (11.1)

AEs, adverse events; ALT, alanine aminotransferase; AST, aspartate aminotransferase.