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. 2021 Aug 4;35:20587384211034086. doi: 10.1177/20587384211034086

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© The Author(s) 2021

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Sulforaphane protected against cisplatin-induced hair cell damage in vitro. A: Cochlear organotypic culture, with myosin7a staining. A’: Myosin 7a⁺ cell counting. After cisplatin (10 μM) treatment, the number of myosin 7a⁺ cells decreased significantly. Myosin 7a⁺ cell numbers were significantly higher in the sulforaphane +Cis group (10 and 15 μM) comparing to the cisplatin (10 μM) group. B: HEI-OC1 cells culture. Cisplatin (10 μM) induced HEI-OC1 cell death. However, incubated with sulforaphane (5, 10, and 15 μM) prevented cisplatin-induced HEI-OC1 cell death. C: HEI-OC1 cell viability. After treatment with cisplatin (10 μM), HEI-OC1 cell viability decreased to 42%, while sulforaphane (5, 10, and 15 μM) significantly prevented the decrease induced by cisplatin (Scale bar = 25 μm. Red indicates myosin7a, blue indicates DAPI. ^*p < 0.05, ^****p < 0.0001, versus cisplatin group; 3 in each group, n = 15).