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. 2021 Aug 4;35:20587384211034086. doi: 10.1177/20587384211034086

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© The Author(s) 2021

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — Sulforaphane prevented disruption of the histone deacetylase / histone deacetylase balance. The addition of sulforaphane 15 μM significantly inhibited the decrease of H3-Ack9 expression induced by cisplatin (10 μM). The addition of sulforaphane (5, 10, and 15 μM) significantly inhibited the increase of HDAC2, -4, and -5 expression induced by cisplatin (10 μM). There was no observed difference between the different sulforaphane concentrations. The addition of sulforaphane or treatment with cisplatin (10 μM) and the expression of HDAC7 and HDAC9 did not change significantly. A: Western blot. The relative protein expression levels of H3-Ack9 (B), HDAC2 (C), HDAC4 (D), HDAC5 (E), HDAC7 (F), and HDAC9 (G) were quantified using Image-Pro Plus 6.0 and normalized to GAPDH (^**p < 0.01, ^***p < 0.001, ^****p < 0.0001; n = 15).