Figure 1.

Renal hilum SUV increased in anti-dsDNA Ab+ mice. (a) Illustrates the three-compartment model. C _B , C₁, and C₂ represent tracer in the blood (input function), activity concentration in the parenchyma, and urine, respectively. (b) Cortex and renal hilum were delineated based on CT. There was no difference in K₁ (c) and f₂ (e) between the groups, but k₂ (d) increased during SLE progression. Area-under-curve of renal hilum (f) increased during SLE progression, while AUCs of cortex (g) and whole kidney (h) were steady. (c)–(h) One-way ANOVA with post-hoc analysis (Dunn’s multiple comparisons test). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.