Table 1.
Characteristics of controls and individuals with incident atrial fibrillation at study entry
| Individuals with incident atrial fibrillation |
||||||
| By sex | By socioeconomic status | |||||
| Comparisons | All AF | Male | Female | Quintile 1 | Quintile 5 | |
| Age category at diagnosis (years) | (n=199 433) | (n=199 433) | (n=99 281) | (n=100 152) | (n=33 632) | (n=44 466) |
| Age at diagnosis (years) | 75.7 (12.7) | 75.8 (12.7) | 72.7 (13.1) | 78.9 (11.5) | 76.3 (12.8) | 75.0 (12.8) |
| Women | 100152 (50.2%) | 100152 (50.2%) | •• | •• | 16797 (49.9%) | 22241 (50%) |
| Socioeconomic status quintile | ||||||
| Quintile 1 (least deprived) | 33360 (16.7%) | 33632 (16.9%) | 16835 (17%) | 16797 (16.8%) | •• | •• |
| Quintile 5 (most deprived) | 40915 (20.5%) | 44466 (22.3%) | 22225 (22.4%) | 22241 (22.2%) | •• | •• |
| Smoking | 32130 (16.1%) | 86207 (43.2%) | 53004 (53.4%) | 33203 (33.2%) | 13026 (38.7%) | 21902 (49.3%) |
| CHA₂DS₂-VASc ≥ 1 for men or ≥2 for women | 171889 (86.2%) | 173354 (86.9%) | 82484 (83.1%) | 90870 (90.7%) | 28765 (86.5%) | 38875 (87.4%) |
| Comorbidities | ||||||
| Hypertension | 45182 (22.7%) | 99644 (50.0%) | 46309 (46.6%) | 53335 (53.3%) | 16224 (48.2%) | 22886 (51.5%) |
| Diabetes | 12487 (6.3%) | 31099 (15.5%) | 17064 (17.2%) | 13945 (13.9%) | 4471 (13.3%) | 7704 (17.3%) |
| Valvular disease | 1941 (1%) | 20467 (10.3%) | 9870 (9.9%) | 10597 (10.6%) | 3656 (10.9%) | 4417 (9.9%) |
| Angina | 14858 (7.5%) | 37846 (19.0%) | 20854 (21.0%) | 16992 (17.0%) | 5657 (16.8%) | 9810 (22.1%) |
| Ischemic heart disease | 10349 (5.2%) | 33358 (16.7%) | 19897 (20.0%) | 13461 (13.4%) | 5289 (15.7%) | 7961 (17.9%) |
| Heart failure | 791 (0.4%) | 41925 (21.0%) | 20236 (20.4%) | 21689 (21.7%) | 6254 (18.6%) | 10297 (23.2%) |
| Stroke | 7363 (3.7%) | 23208 (11.6%) | 10897 (11.0%) | 12311 (12.3%) | 3715 (11.0%) | 5290 (11.9%) |
| Asthma | 12828 (6.4%) | 30252 (15.2%) | 14059 (14.2%) | 16193 (16.2%) | 4908 (14.6%) | 7425 (16.7%) |
| Hyperthyroidism | 1932 (1%) | 4825 (2.4%) | 1028 (1.0%) | 3797 (3.8%) | 730 (2.2%) | 1178 (2.6%) |
| Cancer | 20306 (10.2%) | 38976 (19.5%) | 20263 (20.4%) | 18713 (18.7%) | 6805 (20.2%) | 8354 (18.8%) |
| Chronic kidney disease | 4121 (2.1%) | 40362 (20.2%) | 18985 (19.1%) | 21377 (21.3%) | 6222 (18.5%) | 9750 (21.9%) |
| Chronic obstructive pulmonary disease | 8207 (4.1%) | 25795 (12.9%) | 14182 (14.3%) | 11613 (11.6%) | 3377 (10.0%) | 7306 (16.4%) |
| Dementia | 4674 (2.3%) | 12254 (6.1%) | 4354 (4.4%) | 7900 (7.9%) | 2105 (6.3%) | 2647 (6.0%) |
| Two or more comorbidities | 36176 (18.1%) | 118661 (59.5%) | 57925 (58.3%) | 60736 (60.6%) | 18870 (56.1%) | 27877 (62.7%) |
| Oral anticoagulants prescription | ||||||
| At study entry | 2950 (1.5%) | 20093 (10.1%) | 11280 (11.4%) | 8813 (8.8%) | 3414 (10.2%) | 4458 (10.0%) |
| During follow-up | 4705 (2.4%) | 64646 (32.4%) | 35540 (35.8%) | 29106 (29.0%) | 11307 (33.6%) | 14326 (32.2%) |
Data are mean (SD) or n (%). Socioeconomic status refers to Index of Multiple Deprivation 2015 quintile, with SES 1 referring to the most affluent and SES 5 to the most deprived socioeconomic quintile. Number of comorbidities refers to any of the 13 conditions listed. AF patients characteristics between sex difference: p all <0.001 except for socioeconomic status quintile (p=0.30); between the least and most deprivation difference: p all <0.001 except for sex (p=0.84), dementia prevalence (p=0.07), oral anticoagulants prescription at baseline (p=0.56)