Table 1.
Comparison of diagnosis groups on demographic, clinical, and neuroimaging variables￥
| Variable name | Alzheimer’s (n = 12) | Mild cognitive impairment (n = 17) | Normal (n = 20) | p |
|---|---|---|---|---|
| Age at Visit (mean years) | 71.37 ± 8.01 | 76.35 ± 5.82 | 70.73 ± 8.04 | 0.0589 |
| Sex | 0.5762 | |||
| Female | 8 (66.7%) | 8 (47.1%) | 12 (60.0%) | |
| Male | 4 (33.3%) | 9 (52.9%) | 8 (40.0%) | |
| Subject Race | 0.1972 | |||
| African American | 4 (33.3%) | 3 (17.6%) | 9 (45.0%) | |
| White | 8 (66.7%) | 14 (82.4%) | 11 (55.0%) | |
| Education (mean years) | 14.50 ± 3.34 | 15.63 ± 2.22 | 16.35 ± 2.62 | 0.1828 |
| Clinical Characteristics | ||||
| Cognitive Change Index (CCI) | 34.50 ± 9.26 | 31.69 ± 12.75 | 25.05 ± 9.30 | 0.1125 |
| Self CCI Total Score | 53.25 ± 14.66 | 49.50 ± 20.16 | 37.60 ± 14.91 | 0.0753 |
| Informant CCI Total Score | 77.45 ± 20.20 | 52.27 ± 14.30 | 28.28 ± 13.96 | <0.0001*,† |
| Montreal Cognitive Assessment | 10.00 ± 6.22 | 21.12 ± 3.39 | 24.75 ± 3.74 | <0.0001*,† |
| Global Clinical Dementia Rating | 1.42 ± 0.76 | 0.50 ± 0.00 | 0.10 ± 0.21 | <0.0001*,† |
| Body Mass Index (kg/m2) | 29.60 ± 5.68 | 27.23 ± 3.17 | 27.57 ± 5.80 | 0.4457 |
| Hypertension (UDS Health History) | 6 (50.0%) | 12 (70.6%) | 11 (55.0%) | 0.5694 |
| Diabetes (UDS Health History) | 0 (0.0%) | 3 (17.6%) | 4 (20.0%) | 0.3390 |
| Hypercholesterolemia (UDS Health History) | 5 (41.7%) | 14 (82.4%) | 11 (55.0%) | 0.0596 |
| Cardiovascular disease | 1 (8.3%) | 1 (5.9%) | 5 (25.0%) | 0.3006 |
| Congestive Heart Failure (UDS Health History) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | |
| Neuroimaging Variables | ||||
| MRI data (n = 42) | (n = 9) | (n = 14) | (n = 19) | |
| Total Intracranial volume | 1,365,890 ± 94,169 | 1,480,401 ± 136,342 | 1,482,096 ± 215,244 | 0.2140 |
| Bilateral mean hippocampal volume | 2,855.6 ± 356.36 | 3,120.0 ± 464.00 | 3,653.8 ± 445.40 | <0.0001*,† |
| Cerebral blood flow in the global cerebral cortex | 25.83 ± 5.07 | 32.34 ± 7.71 | 30.40 ± 8.08 | 0.1653 |
| Cerebral blood flow in the bilateral hippocampus | 18.79 ± 6.83 | 23.13 ± 10.26 | 22.65 ± 7.72 | 0.4537 |
| Total white matter hyperintensities | 1.78 ± 1.73 | 3.33 ± 5.15 | 1.37 ± 2.38 | 0.2750 |
| Amyloid PET data (n = 38) | (n = 8) | (n = 12) | (n = 18) | |
| Amyloid burden‡ bilateral global cortical grey matter | 48.70 ± 15.50 | 15.67 ± 27.95 | −4.97 ± 13.03 | <0.0001*,† |
| Amyloid burden‡ bilateral lateral parietal lobe | 51.03 ± 18.53 | 19.37 ± 29.91 | −3.08 ± 15.34 | <0.0001*,† |
| Amyloid burden‡ bilateral precuneus | 73.35 ± 21.06 | 36.84 ± 38.53 | 5.41 ± 19.76 | <0.0001*,† |
| Tau PET data (n = 23) | (n = 3) | (n = 8) | (n = 12) | |
| Tau burden¶ in the medial temporal lobe | 2.34 ± 0.20 | 1.24 ± 0.21 | 1.15 ± 0.08 | <0.0001* |
| Tau burden¶ in the inferior parietal lobule | 2.75 ± 1.12 | 1.22 ± 0.26 | 1.11 ± 0.08 | <0.0001* |
| Tau burden¶ in the lateral temporal lobe | 2.38 ± 0.62 | 1.20 ± 0.23 | 1.12 ± 0.08 | <0.0001* |
￥
Results are from univariate analysis of variance models for continuous variables and Fisher’s exact tests for categorical variables;
*
Pairwise Dunnett or Sidak adjusted comparison between Dementia and Normal is significant (p < 0.05);
†
Pairwise Dunnett or Sidak adjusted comparison between MCI and Normal is significant (p < 0.05);
‡
Mean Centiloid value;
¶
Mean [18F] flortaucipir SUVR.