. Author manuscript; available in PMC: 2021 Aug 9.

Published in final edited form as: J Alzheimers Dis. 2020;75(3):959–969. doi: 10.3233/JAD-191293

Table 3.

Results from analysis Of covariance (ANCOVA) of models of angiogenesis ratio^* on neuroimaging measures^† adjusted for age, sex, and intracranial volume^‡

Model	Dependent variable	Covariates	ParameterEstimate	StandardError	p
1	Total white matter hyperintensities	Age at Visit	0.19	0.07	0.0059
		Sex: Female	2.48	1.37	0.0792
		Total Intracranial volume^*^,‡	0.74	0.040	0.0704
		Angiogenesis ratio^*^,‡	3.47	1.00	0.0013
2	Hippocampal Volume	Age at Visit	−25.67	9.66	0.0115
		Sex: Female	248.46	201.90	0.2262
		Total Intracranial volume^*^,‡	160	60	0.0110
		Angiogenesis ratio^*^,‡	−83.98	146.51	0.5700
3	Hippocampal Blood Flow	Age at Visit	−0.22	0.19	0.2446
		Sex: Female	5.78	3.83	0.1424
		Total Intracranial volume^*^,‡	0.055	1.2	0.9615
		Angiogenesis ratio^*^,‡	−0.49	2.87	0.8644
4	Cerebral Blood Flow	Age at Visit	−0.26	0.16	0.1219
		Sex: Female	6.52	3.37	0.0625
		Total Intracranial volume^*^,‡	1.6	0.99	0.1195
		Angiogenesis ratio^*^,‡	0.48	2.53	0.8495

Pro-angiogenic to non-angiogenic circulating hematopoietic stem and progenitor cells;

^†

N = 46;

^‡

Total intracranial volume in 100,000 mm³.