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. 2021 Aug 9;125(12):1602–1611. doi: 10.1038/s41416-021-01519-2

Fig. 2. Schematic overview of the Hippo signalling pathway.

Fig. 2

(Left) When Hippo signalling is off, YAP enters the nucleus, interacts with TEAD and recruits other factors to induce gene transcription. (Right) When Hippo signalling is on, YAP is phosphorylated by LATS1/2 on multiple sites, resulting in interaction with 14-3-3 and cytoplasmic retention; phosphorylation also leads to YAP poly-ubiquitination and degradation. TEAD does not bind with YAP and target gene transcription is suppressed. MST1/2 mammalian Ste20-like kinase 1/2, SAV Salvador non-catalytic scaffold protein, LATS1/2 large tumour suppressor 1/2, YAP Yes-associated protein, Mob1 Mps one binder kinase activator-like 1, TEAD TEA domain family member 1, ABL Abelson murine leukaemia viral oncogene, β-Trcp β-transducin repeat-containing protein, NF2 neurofibromin 2.