Figure 1. RCI-Based Outcomes on Observer-Rated Executive Functions Following 24 and 48 Weeks of Treatment.

BRIEF BRI = Behavior Rating Inventory of Executive Functioning, Behavioral Regulation Index; BRIEF MCI = Behavior Rating Inventory of Executive Functioning, Metacognition Index; CI = confidence interval; MEK = received mitogen-activated protein kinase inhibitor; RCI = Reliable Change Index. *Significantly different from normative (expected) proportions using 2-tailed 90% CI.