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. 2021 Aug 9;19:339. doi: 10.1186/s12967-021-03004-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Dysregulated DNA damage response in gastric cancer unraveled by quick label-free phosphoproteomics. a Phosphopeptide ratio distribution. b Volcano plot to show the differential phosphoproteins with unique phospho-sites in gastric cancer and paired non-tumor tissues, with candidate phosphoproteins marked, including BCLAF1 (dark red). The red points represented the up-regulated phosphoproteins, while blue points represented the down-regulated phosphoproteins. Multiple hypothesis testing based on FDR. c PPI of up-regulated phosphoproteins. d PPI of down-regulated phosphoproteins. e The chord diagram of enrichment analysis for the up-regulated phosphoproteins. f The chord diagram of enrichment analysis for the down-regulated phosphoproteins. g GSEA analysis of the DEPs between gastric cancer and paired non-tumor tissues. h GSVA was used to analyze these DEPs closely related to DNA repair