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Longitudinal trajectories of (A) gray matter (GM) volume, white matter (WM) volume, and (B) white matter hyperintensity (WMH) lesion volume for placebo and simvastatin groups over 18 months. The simvastatin group showed significantly different percent change in total WM volume at 12 and 18 months compared to the placebo group. There were no significant differences in GM or WMH volume changes between placebo and simvastatin groups. * P < 0.05.
