. 2021 Jun 22;8(8):1576–1591. doi: 10.1002/acn3.51363

Table 2.

Psychosis and perceptual abnormalities across the spectrum of ALS‐FTD.

	ALS (n = 28)	ALS‐P (n = 9)	ALS‐FTD (n = 11)	bvFTD (n = 27)	Controls (n = 25)	X ²	p value	Effect size		X ²	p value
Psychosis present on CBI‐R (%)	18	22	55	39	—	5.36	0.15	0.271
CAPS ‐ Clinical Psychosis Factor
Symptom endorsed (%)	21.4	33.3	45.5	37	0	13.7	0.008	0.370	bvFTD > HC	11.464	0.001
									ALS‐FTD > HC	13.196	<0.001
									ALS‐P > HC	9.140	0.003
									ALS > HC	6.04	0.01
Thought broadcast (%)	18	22	27	22	0	9.33	0.05	0.305
Thoughts repeated (%)	18	0	18	22	0	6.91	0.14	0.263
Third person voices (%)	7	11	27	11	0	6.25	0.17	0.254
Visual hallucinations (%)	11	0	18	22	0	8.28	0.09	0.287
CAPS – Perceptual Abnormality Domains
Auditory (%)	25	33	73	41	8	14.77	0.005	0.392	ALS‐FTD > ALS	7.6	0.006
Auditory (%)	25	33	73	41	8	14.77	0.005	0.392	ALS‐FTD > HC	13.42	<0.001
Visual (%)	14	22	55	26	4	13.06	0.011	0.363	ALS‐FTD > HC	11.97	<0.001
Visual (%)	14	22	55	26	4	13.06	0.011	0.363	ALS‐FTD > ALS	6.71	0.01
Taste (%)	32	33	54	33	0	14.13	0.007	0.378	bvFTD > HC	9.71	0.002
									ALS‐FTD > HC	15.8	<0.001
									ALS > HC	9.33	0.002
Smell (%)	21.4	33	73	22	0	22.75	<0.001	0.479	ALS‐FTD > HC	21.874	<0.001
									ALS‐P>HC	8.46	0.004
									ALS‐FTD>bvFTD	8.57	0.003
									ALS‐FTD>ALS	9.03	0.003
Touch (%)	46	56	82	33	4	23.7	<0.001	0.487	ALS‐FTD>bvFTD	7.37	0.007
									ALS‐FTD>HC	23.06	<0.001
									bvFTD>HC	7.2	0.007
									ALS‐P>HC	12.1	0.001
									ALS>HC	12.23	<0.001
Psychiatric (%)	4	22	36	33	0	17.7	0.001	0.42	bvFTD>ALS	8.19	0.004
									ALS‐FTD>ALS	7.6	0.006
									bvFTD>HC	10.08	0.002
									ALS‐FTD>HC	10.28	0.001
Neuropathy (%)	43	33	64	19	4	18.5	0.001	0.43	ALS‐FTD>bvFTD	7.36	0.007
									ALS‐FTD>HC	15.72	<0.001
									ALS>HC	10.77	0.001

Values are expressed as percentages of the cohort experiencing at least one psychotic symptom and also each separate question for the CAPS – clinical psychosis factor. Values are also expressed as percentages of the cohort experiencing at least one perceptual abnormality for each CAPS perceptual abnormality domain. Significant values are highlighted in bold. X ² represents the chi‐square value and effect size is measured as Kramer's V.