Table 4.
Psychosocial factors across the spectrum of ALS‐FTD.
| ALS (n = 28) | ALS‐Plus (n = 9) | ALS‐FTD (n = 11) | bvFTD (n = 27) | Controls (n = 25) | F value | p value | Effect size | Post hoc | p value | 95% Confidence intervals | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Depression | 4.4 ± 5.0 | 6.7 ± 7.3 | 8.7 ± 7.6 | 8.9 ± 10.4 | 0.6 ± 1.4 | 4.89 | 0.001 | 0.19 | bvFTD > HC | 0.001 | 2.37–14.13 |
| ALS‐FTD > HC | 0.02 | 0.75–15.3 | |||||||||
| Anxiety | 3.4 ± 2.8 | 6.3 ± 6.3 | 7.3 ± 7.0 | 6.6 ± 8.8 | 0.2 ± 0.6 | 4.92 | 0.001 | 0.19 | bvFTD > HC | 0.003 | (−11.28) to (−1.58) |
| ALS‐FTD > HC | 0.01 | (−13.16) to (−1.14) | |||||||||
| Social isolation | 1.4 ± 2.1 | 1.6 ± 1.9 | 4.3 ± 3.2 | 2.9 ± 3.0 | 0.6 ± 1.2 | 5.94 | <0.001 | 0.22 | bvFTD > HC | 0.02 | 0.26–4.37 |
| ALS‐FTD > ALS | 0.007 | 0.53–5.23 | |||||||||
| ALS‐FTD > HC | 0.001 | −6.13 to −1.17 | |||||||||
| Social anxiety | 1.4 ± 1.6 | 1.2 ± 1.5 | 2.0 ± 2.2 | 1.8 ± 2.4 | 0.6 ± 1.3 | 1.7 | 0.1 | 0.07 |
Values are expressed as mean ± standard deviation. Significant values are highlighted in bold. Effect size measured as Eta2.