Table 1.
Baseline and longitudinal PK11195 uptake.
|
DVR values (mean ± SD) |
NAWM | Lesion | GM | TH | CAU | PU | HIPP | AMG |
|---|---|---|---|---|---|---|---|---|
|
BL (n = 15) |
1.15 ± 0.06 | 1.03 ± 0.11 | 1.10 ± 0.04 | 1.37 ± 0.13 | 0.96 ± 0.10 | 1.29 ± 010 | 1.19 ± 0.10 | 1.23 ± 0.10 |
|
6 mo (n = 15) |
1.15 ± 0.07 | 0.99 ± 0.19 | 1.11 ± 0.04 | 1.39 ± 0.11 | 0.95 ± 0.13 | 1.30 ± 0.10 | 1.20 ± 0.11 | 1.22 ± 0.11 |
| 12 mo (n = 14) | 1.16 ± 0.06 | 1.01 ± 0.13 | 1.12 ± 0.03 | 1.41 ± 0.11 | 0.96 ± 0.13 | 1.30 ± 0.09 | 1.20 ± 0.10 | 1.23 ± 0.11 |
| 24 mo (n = 10) | 1.16 ± 0.07 | 1.01 ± 0.14 | 1.12 ± 0.05 | 1.39 ± 0.14 | 0.97 ± 0.11 | 1.30 ± 0.11 | 1.21 ± 0.12 | 1.23 ± 0.11 |
|
HC (n = 16) |
1.1 ± 0.04 | N/A | 1.07 ± 0.11 | 1.27 ± 0.08 | 0.91 ± 0.10 | 1.19 ± 0.07 | 1.09 ± 0.07 | 1.07 ± 0.08 |
| P values | ||||||||
| BL versus HC | 0.05 | 0.01 | 0.41 | 0.03 | 0.11 | 0.01 | 0.01 | 0.00 |
| BL versus 6 mo | 0.55 | 0.13 | 0.40 | 0.27 | 0.36 | 0.56 | 0.80 | 0.37 |
| BL versus 12 mo | 0.01 | 0.48 | 0.04 | 0.04 | 0.53 | 0.02 | 0.36 | 0.89 |
| BL versus 24 mo | 0.49 | 0.88 | 0.21 | 0.43 | 0.96 | 0.53 | 0.34 | 0.50 |
| 12mo versus 24 mo | 0.10 | 0.43 | 0.70 | 0.72 | 0.45 | 0.89 | 0.52 |
0.97 |
Abbreviations: DVR, distribution volume ratio, BL, baseline for MS patients, mo, month, SD, standard deviation, HC, healthy control, NAWM, normal‐appearing white matter, Lesion, whole lesion mask, GM, cortical gray matter, TH, thalamus, CAU, caudate, PU, putamen, HIPP, hippocampus, AMG, amygdala.