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. 2021 Jul 23;11:715593. doi: 10.3389/fonc.2021.715593

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Copyright © 2021 Yang, Chen, Zhang, Xiong, Wang, Fang, Li, Fei and Gong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockdown of ME2 inhibits migration and invasion of GBM cells. (A) Representative images of the migration of LN229 cells transfected with vector or Flag-ME2 plasmids (***P < 0.0001). (B) Numbers of migrated cells after Flag-ME2 transfection in U87MG cells (***P < 0.0001). (C, D) Representative images of the migration distances of LN229 and U87MG cells transfected with sh-EGFP or sh-ME2 plasmids (***P < 0.0001). (E, F) Invasion ability of LN229 and U87MG cells transfected with sh-EGFP or sh-ME2 plasmids determined by transwell invasion assay (***P < 0.0001).