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. 2021 Jul 23;11:715593. doi: 10.3389/fonc.2021.715593

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Copyright © 2021 Yang, Chen, Zhang, Xiong, Wang, Fang, Li, Fei and Gong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ME2 promotes PMT and inhibits the production of ROS in mitochondria. (A, B) Western blots confirming the expression of MET, E-cadherin, N-cadherin, vimentin, YKL-40, and OLIG2 (A) in SW1783 and U251MG cells transfected with vector or Flag-ME2 plasmids and (B) in LN229 and U87MG cells transfected with sh-EGFP or sh-ME2 plasmids. (C, D) Changes in ROS in mitochondria of SW1783 and U251MG cells transfected with vector or Flag-ME2 plasmids detected by fluorescent probe. Green fluorescence represents lipid components oxidized by ROS; red fluorescence represents nonoxidized lipid components. Fluorescence intensity statistics and analysis by Image J (*P < 0.05).